to see the proof and a complete list of references, visit idexx.eu/sdma. Serum sdma helps in the prediction of the impact of the hyperthyroidism treatment on kidney function test in cats and helps in identifying which cat will become azotemic after treatment.
A new test can predict kidney disease in cats two years
An elevated sdma concentration is a reflection of impaired glomerular filtration rate (gfr).
Sdma test in cats. In fact, more than half of cats over age 15 are afflicted. Sdma is a breakthrough new test that not only screens for kidney disease, but can detect this devastating disease months to years earlier than previously possible. Greater than 16g/dl in puppies) is considered meaningful.
All the research ive seen on the use of sdma in dogs and cats (including the study referenced above) has. Both in cats and dogs, it is stable for one week at room temperature. To demonstrate that sdma remains relatively stable in the face of both muscle loss and hyperfiltration, a large retrospective data analysis 3 was performed comparing creatinine and sdma results in cats older than 5 years of age.
In cats or dogs (with or without ckd) that present with obvious muscle wasting, sdma might give a more accurate estimate of kidney dysfunction than serum creatinine. The sdma test, available commercially this past july, is a real breakthrough. Hyperthyroid cats like zeke will often have normal creatinine levels, even when they have chronic kidney disease (ckd).
With the idexx sdma test, over 2 times the number of pets could be diagnosed with kidney disease.5 sdma increased, Sdma may be useful for helping confirm the ckd diagnosis, but once your cat has had a positive test, repeating the test is unlikely to be of value in most cases, though early diagnosis of chronic kidney disease in dogs and cats: In addition, sdma is much less affected by dehydration and protein loss than bun and creatinine.
However hypothyroidism is quite rare in cats (except for those treated with radioactive iodine) so it would be difficult to test this theory (peterson et al). Some estimates are as high as one in two (fifty percent), and eighty percent of cats over the age of fifteen will suffer from this awful disease. Comparison of sdma to other kidney diagnostics 7.
The idexx sdma test will help 1 in 3 cats is your cat the 1. The idexx sdma test identified chronic kidney disease (ckd) in zeke despite his weight loss and concurrent thyroid disease. Now idexx sdma, a breakthrough new test that screens for kidney disease, can detect this devastating disease months to years earlier.
Idexx launches new kidney function test for cats and dogs. Sdma is more reliable than creatinine as an indicator of kidney function because it is not influenced by confounding conditions, such as muscle mass or diet. Serum sdma concentration was more accurately correlated with gfr in these cats, and, unlike scr, sdma increased as gfr declined with age.
Here's what they have to say about the sdma test: Sdma faqs answers frequently asked questions about the sdma test. Any increase in sdma concentration above the reference interval (greater than 14 g/dl in cats and adult dogs;
1 in 3 cats & 1 in 10 dogs get kidney disease. There was, however, a benefit in using sdma versus scr to assess kidney function in older cats with muscle wasting. Finding a high serum sdma concentration in a hyperthyroid cat can help predict development of azotemia after treatment.
Sdma is an earlier indicator of progressive kidney function loss, often increasing. Greater than 16 g/dl in puppies) is considered meaningful. Use of serum creatinine and symmetric dimethylarginine (2016) grauer gf today's veterinary practice mar/apr.
you can read the full statement here: Sdma increases earlier than creatinine in dogs and cats as kidney function decreases. Therefore, as kidney function or gfr decreases, sdma increases.
While its clear many cats are at risk, there is good news. 3 sdma gives you and your veterinarian the chance to take action sooner and gives your cat the best shot for a healthy, happy, long life even with kidney disease. New screening gives cats and dogs best chance against kidney.
Serum or heparinized plasma can be used for the performing test. Sdma is an exciting new test that will allow your veterinarian to monitor changes in values over time to help evaluate response to therapy/treatment, monitor progression of renal disease, decide when additional treatments should be added, and identify sudden worsening in your cats chronic kidney disease. An elevated sdma concentration is a reflection of impaired glomerular filtration rate (gfr).
3 this gives you and your veterinarian the chance to take action and give your pet the best shot for a healthy, happy, long life even with kidney. Sdma is a sensitive indicator of kidney function that detects as little as 25% loss of function. This far outnumbers cats with thyroid disease or diabetes.
Any increase in sdma concentration above the reference interval (greater than 14 g/dl in cats and adult dogs; In a recent study, prior to hyperthyroid treatment, the idexx sdma test was increased in about half of the cats that had a normal creatinine before hyperthyroid treatment but become azotemic after thyroid treatment. And unlike creatinine, sdma is not impacted by muscle mass. *symmetric dimethylarginine.
Before this new test, dogs and cats were only diagnosed when they showed symptoms of kidney disease. Sdma is excreted from the kidneys; The idexx sdma test is an early detection tool for kidney disease in cats and dogs.
8 therefore, while a normal pretreatment sdma concentration does not rule out the possibility of a hyperthyroid cat developing azotemia, it is much more reliable than creatinine for identifying. R2 of 0.85 in dogs. For now, well have to take their word on that.
Sdma can catch changes when only 25 percent of kidney function is lost, giving cats a better chance to respond to treatment. How does sdma relate to glomerular filtration rate (gfr)? On average, sdma detected kidney disease when only 40% of function had been lost and, in some cases, 25% of function.
Chronic kidney disease is a major cause of mortality in dogs and cats. Its said that one in three cats will be diagnosed with kidney disease in its lifetime. It also compared the number of cats with kidney disease identified by creatinine versus.
Idexx s sdma test diagnoses cat kidney disease earlier paws for. But, as with any promising new biomarker, there is a need for additional studies. Sdma is a more reliable indicator of kidney function in hyperthyroid cats than creatinine.
These new tests allow for earlier detection and intervention with kidney disease in cats. Studies have shown a very strong correlation between sdma and gfr (r2 of 0.82 in cats; Approximately 1 in 3 cats and 1 in 10 dogs will eventually develop kidney disease.
These findings suggest that by using the idexx sdma test, veterinarians have the potential opportunity to diagnose kidney disease 2.5 times more in cats and 2.2 times more in dogs, compared to traditional methods. Clearly sdma has utility for the diagnosis and management of dogs and cats with renal disease. In the above study, cats that developed azotemia after radioactive iodine therapy were more likely to be hypothyroid, suggesting hypothyroidism may cause decreased gfr and increased sdma concentrations.
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